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Products for use in the clinical diagnosis of viral infections, including SARS-CoV-2, the virus that causes COVID-19, by simultaneously measuring multiple analytes from a single sample.
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The Meso Scale Discovery V-PLEX Human IL-17C Kit is used to quantitatively measure human interleukin 17C (IL-17C) in cell culture supernatants serum plasma and other biological fluids This electrochemiluminescent immunoassay utilizes MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible results from a small sample volume The kit includes a 96-well plate pre-coated with capture antibody detection antibody conjugated to ruthenium calibrators and diluent The assay has a typical lower limit of detection of 0 05 pg/mL and an upper limit of quantification of 2500 pg/mL
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The Meso Scale Discovery V-PLEX Mouse Cytokine 30-Plex Kit is an electrochemiluminescent immunoassay for measuring 30 mouse cytokines chemokines and growth factors in various biological fluids It includes a 96-well plate with capture antibodies detection antibodies with an electrochemiluminescent label calibrators controls diluent wash buffer read buffer and plate seals The assay features a dynamic range of 3-4 logs high sensitivity and requires 25-50 L of sample It runs on MSD s SECTOR Imager for efficient cytokine profiling
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The V-PLEX Mouse Cytokine 30-Plex Kit from Meso Scale Discovery is a multiplex immunoassay for measuring 30 mouse cytokines and chemokines in one well It includes a 96-well plate with capture antibodies detection antibodies calibrators diluent read buffer wash buffer and plate seals Using electrochemiluminescence it offers high sensitivity and a broad dynamic range It measures IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 IL-9 IL-10 IL-12p40 IL-12p70 IL-13 IL-15 IL-17A Eotaxin G-CSF GM-CSF IFN- CXCL1 CCL2 CCL3 CCL4 CCL5 CXCL10 TNF- VEGF-A CCL11 LIF CXCL2 and CXCL5 in various samples
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A polyphenol flavonoid reduces iron- and ascorbate-induced lipid peroxidation of isolated bovine brain phospholipid liposomes (IC50 20 UM) inhibits HCV RdRp by 17 7 in an enzyme assay
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12(S)-hydroxy-16-Heptadecynoic acid is a mechanism-based inhibitor of CYP450 W-hydroxylase.{1051} It inhibits prostaglandin W-hydroxylase with a Ki value of 1.8 UM.{1051}
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The Meso Scale Discovery COVID-19 Coronavirus Panel 2 IgG is an in vitro diagnostic test kit that detects IgG antibodies to SARS-CoV-2 in human serum and plasma It uses electrochemiluminescence technology on Meso Scale Discovery s proprietary MULTI-ARRAY platform The test has high sensitivity and specificity and is intended as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection Results are available in approximately 2 hours The test kit includes a 96-well plate coated with SARS-CoV-2 antigens detection antibodies calibrators and controls
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The Mesoscale K15562U-2 is a high-performance thermoelectric cooler designed for precision temperature control applications It measures 15mm x 15mm x 3 4mm and provides a maximum heat pumping capacity of 2 5W at 27 C temperature difference This solid-state active cooling device uses the Peltier effect for heating or cooling and requires an external power supply up to 6V With no moving parts it provides maintenance-free operation The K15562U-2 can reach below-ambient temperatures as low as -10 C when paired with a suitable heat sink Key applications include stabilizing laser diode temperatures and cooling small chambers
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The Mesoscale K15661U-2 is a high-performance thermoelectric module for cooling applications with a 15W heat pumping capacity and a 68 C max temperature difference It has 127 Bismuth Telluride alloy thermocouples between ceramic substrates measures 40 x 40 x 3 4mm and weighs 10g It operates at a no-load voltage of 2 7V and requires 6A for optimal performance Suitable for refrigerators wine coolers and medical instruments it offers solid-state maintenance-free quiet and reliable operation
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The Meso Scale Discovery V-PLEX Plus Viral Panel 2 Human Kit is a multiplex immunoassay that simultaneously detects antibodies to SARS-CoV-2 Influenza A Influenza B and RSV in human serum and plasma This assay kit contains a 96-well plate coated with antigens for the viruses detection antibodies standards controls diluent wash buffer read buffer and plate seals The electrochemiluminescence technology allows sensitive and accurate quantification of antibody levels This product enables efficient serological testing for current or past exposure to common respiratory viruses
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The Meso Scale Discovery V-PLEX Plus Metabolic Panel 1 Human Kit quantifies insulin leptin resistin PAI-1 active and MCP-1 in human serum plasma and cell culture supernatants This ECL-based assay uses MSD s SULFO-TAG labels and multi-array technology for sensitive reproducible results from a small sample The kit includes a 96-well plate with capture antibodies detection antibodies with ruthenium read buffer calibrators and controls It can be automated with a hands-on time of 2 5 hours and requires a 50 L sample
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The Mesoscale K15562U-4 is a 4-channel 15-bit digital-to-analog converter (DAC) with update rates up to 250 MSPS It has a full scale output voltage range of 2 Vpp and utilizes CMOS technology The DAC has SPI and parallel interfaces and includes features such as dual power supplies and power-down mode With high speed resolution and accuracy this DAC is designed for applications including instrumentation imaging communications and industrial control The converter comes in a compact 32-lead LFCSP surface mount package
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 34 Mouse IgG Kit is a multiplex immunoassay for detecting and quantifying IgG antibodies against 34 SARS-CoV-2 antigens in mouse samples It uses MSD s electrochemiluminescence technology offering high sensitivity and a wide dynamic range compatible with 96-well plate readers The kit includes a plate with 34 antigens detection antibodies calibrators controls buffers and reagents for 96 tests aiding in vaccine development and immunology studies using mouse models
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An alkaloid active against the F32 chloroquine-sensitive (IC50 0 52 UM) and FcB1 and FcM2 chloroquine-resistant strains of P falciparum (IC50s 0 52 0 8 and 0 49 UM respectively) and reduces parasitemia in a mouse model of P vinckei infection (ED50 18 9 mg/kg per day) decreases LPS-induced increases in TNF-a IL-1B and IL-6 levels and p65 nuclear translocation in RAW 264 7 cells at 5 UM decreases serum levels of IL-10 TNF-a and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia inhibits proliferation of various cancer cells (IC50s 2 65-370 ng/ml) induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0 1-10 UM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
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The Meso Scale Discovery V-PLEX Human IL-6 Kit is a highly sensitive and quantitative assay for measuring human interleukin 6 (IL-6) in serum plasma and cell culture supernatants This electrochemiluminescent immunoassay utilizes MSD s proprietary SULFO-TAG labels and multi-array technology to enable simultaneous detection of IL-6 down to 0 05 pg/mL with an upper limit of 10 000 pg/mL The kit includes a 96-well plate pre-coated with capture antibody detection antibody conjugated to ruthenium calibrators and reagents for 50 tests It provides accurate reproducible quantitation of IL-6 levels with high sensitivity and wide dynamic range
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The Meso Scale Discovery V-PLEX Viral Panel 3 Human Kit is a multiplex immunoassay that simultaneously detects antibodies to SARS-CoV-2 Influenza A and Influenza B in human serum and plasma This assay uses electrochemiluminescence technology on patterned arrays for high sensitivity and a wide dynamic range The kit includes a 96-well plate detection antibodies wash buffers calibrators controls and other reagents needed to run the assay Results are obtained in as little as 3 5 hours This kit allows efficient quantitative antibody profiling against multiple viral targets from a single small sample volume
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